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Steroids

steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes which alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plantsanimals and fungi. All steroids are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene.[2]

The steroid core structure is typically composed of seventeen carbon atoms, bonded in four “fused” rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from cholestane.[1]:1785f[3] Steroids can also be more radically modified, such as by changes to the ring structure, for example, cutting one of the rings. Cutting Ring B produces secosteroids one of which is vitamin D3.

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Anabolic-androgenic steroids (also known as AAS) are versions or derivatives of the male sex hormone naturally present testosterone, which is produced naturally in both men and women chemically modified. In other words, steroids refer to drugs (excluding estrogens, progestins, and corticosteroids) or hormonal substance (s), which are chemically related to testosterone that promotes muscle growth.

Today, there are more than a hundred varieties of these medications, but only a few are approved for human or veterinary use and a prescription is required to purchase these drugs for medicinal purposes.

Anabolic steroids are under the Anabolic Steroids Control Act of 1990 in Annex III of the Controlled Substances Act (CSA). These drugs, according to the legislation, are classified as drugs or hormonal substances that are chemically and pharmacologically related to testosterone (other than estrogens, progestins, and corticosteroids), and have the potential to promote muscle

Pain Relief

Pain relievers are medicines that reduce or relieve headaches, sore muscles, arthritis, or other aches and pains. There are many different pain medicines, and each one has advantages and risks. Some types of pain respond better to certain medicines than others. Each person may also have a slightly different response to a pain reliever.

Over-the-counter (OTC) medicines are good for many types of pain. There are two main types of OTC pain medicines: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs.

If OTC medicines don’t relieve your pain, your doctor may prescribe something stronger. Many NSAIDs are also available at higher prescription doses. The most powerful pain relievers are opioids. They are very effective, but they can sometimes have serious side effects. There is also a risk of addiction. Because of the risks, you must use them only under a doctor’s supervision.

There are many things you can do to help ease pain. Pain relievers are just one part of a pain treatment plan.

What is Methadone all About

 Methadone Best Pain Killer

This medication is used to treat addiction to narcotic drugs (such as heroin) as part of an approved treatment program. Methadone belongs to a class of drugs known as narcotic (opiate) analgesics. It helps prevent withdrawal symptoms caused by stopping other narcotic drugs.

Methadone Binds to opiate receptors in the CNS. Alters the perception of and response to painful stimuli, while producing generalized CNS depression. Therapeutic Effects: Decrease in severity of pain. Suppression of withdrawal symptoms during detoxification and maintenance from heroin and other opioids.

INDICATIONS AND USAGE

1. For the treatment of moderate to severe pain not responsive to non-narcotic analgesics.
2. For detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
3. For maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in conjunction with
appropriate social and medical services.

Acute Pain – Maintenance patients on a stable dose of methadone who experience physical trauma, postoperative
pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients
should be administered analgesics, including opioids, in doses that would otherwise be indicated for nonmethadone-treated
patients with similar painful conditions. Due to the opioid tolerance induced by methadone, when
opioids are required for management of acute pain in methadone patients, somewhat higher and/or more frequent
doses will often be required than would be the case for non-tolerant patients.

CONTRAINDICATIONS

Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other
ingredient in DOLOPHINE.
Methadone is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory
depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute
bronchial asthma or hypercarbia.
Methadone is contraindicated in any patient who has or is suspected of having a paralyticileus.

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